Docteur en Psychologie

Université Lille 3
Domaine Universitaire du Pont de Bois
BP 60149
59653 Villeneuve d’Ascq Cedex

Bureau : A4.130

Thème de Recherche

Thèse soutenue : 02 juillet 2015

Titre de la thèse : Brain imaging and neuropsychology in patients with memory disorders

Sous la direction du professeurSéverine SAMSON

Domaine de recherche : psychologie

Résumé

The aim of the project is to explore the benefits of music in memory in patients with memory disorders. the first axis of the project will focus on neuroimaging data to identify the neural network involved in memory for songs. structures within the temporal lobe will be explored at two different levels. on the one hand, integration and separation of lyrics and tunes in healthy control participants, will be contrasted with patient data and analyzed at a perceptual level, following an adaptation effect paradigm. these data obtained in patients with medial temporal lobe epilepsy associated to hippocampal atrophy will provide insights about the possible differences between patients and healthy control participants. on the other hand, at a memory level, encoding processes will be explored by looking into medial temporal lobe structures, known to be tightly involved in memory processing (daselaar, fleck, & cabeza,2006 ; squire, wixted, & clark, 2007). these structures, which role in music memory remain until date to be accurately described (eichenbaum, yonelinas, & ranganath, 2007; noulhiane, samson, clemenceau et al., 2006; watanabe, yagishita & kikyo, 2008), will be carefully examined in order to detect patterns of lateralization and/or integration for both, healthy controls and patients. the second axis of the project will be set up depending on previous results, as an application of the obtained findings. a rehabilitation program based on music and a series of behavioral studies will be developed and carried out in patients with uncontrolled pharmacological temporal lobe epilepsy. the implementation will be done either before surgery, as a prevention measure in patients at risk for post operative memory decline, or after the surgery in comparison with the regular rehabilitation program. the goal of this study will be to try to document the benefits of music on memory and learning abilities of verbal information. a neuroimaging study will be carried out to reflect the reorganization of cerebral network underlying memory abilities in regard to music and it’s effect on verbal domain.

Mise à jour le 07 octobre 2015