Maître de Conférences
Psychologie Cognitive
- Faculté : Univ Lille Nord de France – Université de Lille 3
- Département : Unité de Formation et Recherche en Psychologie
- Laboratoire : PSITEC – EA 4072
- Membre de l’Axe de Recherche Neuropsychologie : Audition, Cognition, Action
- Adresse postale :
Université Lille 3
Domaine Universitaire du Pont de Bois
BP 60149
59653 Villeneuve d’Ascq Cedex
♦ Mots-clés ♦
Émotion, Mémoire, Musique, Temps de réaction visuels et auditifs, Psychométrie cognitive, Troubles cognitifs et socio-émotionnels, Pathologies cérébrales et développementales, Neuropsychologie, Psychophysiologie, Neurophysiologie, Plasticité cérébrale, Chirurgie éveillée.
♦ thèmes de TER (2016-2017) ♦
- Interactions entre mémoire et émotion en modalité musicale et verbale auprès de populations adultes saines, vieillissantes et SEP (sclérose en plaques) en collaboration avec la clinique Sainte Barbe (Fouquières lez Lens) (co-direction Delphine Dellacherie et Séverine Samson)
- Pathologies neurodéveloppementales : théorie de l’esprit, capacités sociales en collaboration avec le CHR de Lille
- Troubles du cervelet chez l’enfant : exploration des aptitudes musicales en collaboration avec le CHR de Lille
- Troubles d’apprentissages et capacités de perception du temps, synchronisation sensori-motrice en collaboration avec le CHR de Lille et l’université de Montpellier
- Capacités graphomotrices, intelligence, potentiel créatif et motivation chez l’enfant sain
- Adaptation chez l’enfant d’une tâche de code à destination des enfants présentant des troubles moteurs
- Adaptation d’une échelle d’amnésie post-traumatique chez l’enfant en collaboration avec le CHR de Lille
prendre rendez-vous pour un entretien : Delphine DELLACHERIE
♦ Publications ♦
2017 |
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| 1. | Omigie, D; Dellacherie, D; Samson, S Effects of learning processes on dissonance judgments, special issue Cognition of Early Polyphony: Bringing Together Humanities and Sciences Article de journal Dans: Journal of Interdisciplinary Music Studies, 8 (142), p. 11-29, 2017. @article{Omigie2017, title = { Effects of learning processes on dissonance judgments, special issue Cognition of Early Polyphony: Bringing Together Humanities and Sciences}, author = {D. Omigie and D. Dellacherie and S. Samson}, url = {http://musicstudies.org/wp-content/uploads/2017/03/Omigie_JIMS_16081201.pdf}, doi = {doi: 10.4407 /jims.2016 . 12 .001}, year = {2017}, date = {2017-03-15}, urldate = {2017-07-17}, journal = {Journal of Interdisciplinary Music Studies}, volume = {8}, number = {142}, pages = {11-29}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
| 2. | Huin, Vincent; Strubi-Vuillaume, Isabelle; Dujardin, Kathy; Brion, Marine; Delliaux, Marie; Dellacherie, Delphine; Cuvellier, Jean-Christophe; Cuisset, Jean-Marie; Riquet, Audrey; Moreau, Caroline; Defebvre, Luc; Sablonnière, Bernard; Devos, David Expanding the phenotype of SCA19/22: Parkinsonism, cognitive impairment and epilepsy Article de journal Dans: Parkinsonism & related disorders, 45 , p. 85–89, 2017. @article{Huin.2017, title = {Expanding the phenotype of SCA19/22: Parkinsonism, cognitive impairment and epilepsy}, author = {Vincent Huin and Isabelle Strubi-Vuillaume and Kathy Dujardin and Marine Brion and Marie Delliaux and Delphine Dellacherie and Jean-Christophe Cuvellier and Jean-Marie Cuisset and Audrey Riquet and Caroline Moreau and Luc Defebvre and Bernard Sablonnière and David Devos}, doi = {10.1016/j.parkreldis.2017.09.014}, year = {2017}, date = {2017-01-01}, journal = {Parkinsonism & related disorders}, volume = {45}, pages = {85--89}, abstract = {INTRODUCTION Spinocerebellar ataxia types 19 and 22 (SCA19/22) are rare conditions in which relatively isolated cerebellar involvement is frequently associated with cognitive impairment. Here, we report on new clinical features and provide details of the cognitive profile in two SCA19/22 families. METHODS Two families displaying an autosomal-dominant form of cerebellar ataxia underwent clinical examinations and genetic testing. RESULTS In addition to the classical clinical features of SCA, a wide spectrum of cognitive disorders (including visuospatial impairments) was observed. Eight patients had mild Parkinsonism, and five had epilepsy. Genetic testing showed that the KCND3 mutation (c.679_681delTTC, p.F227del) was present in both families. CONCLUSIONS Our findings broaden the phenotypic spectrum of SCA19/22, and suggest that KCND3 should be included in the list of candidate genes for epilepsy, Parkinsonism and cognitive impairment.}, keywords = {}, pubstate = {published}, tppubtype = {article} } INTRODUCTION Spinocerebellar ataxia types 19 and 22 (SCA19/22) are rare conditions in which relatively isolated cerebellar involvement is frequently associated with cognitive impairment. Here, we report on new clinical features and provide details of the cognitive profile in two SCA19/22 families. METHODS Two families displaying an autosomal-dominant form of cerebellar ataxia underwent clinical examinations and genetic testing. RESULTS In addition to the classical clinical features of SCA, a wide spectrum of cognitive disorders (including visuospatial impairments) was observed. Eight patients had mild Parkinsonism, and five had epilepsy. Genetic testing showed that the KCND3 mutation (c.679_681delTTC, p.F227del) was present in both families. CONCLUSIONS Our findings broaden the phenotypic spectrum of SCA19/22, and suggest that KCND3 should be included in the list of candidate genes for epilepsy, Parkinsonism and cognitive impairment. |
| 3. | Puyjarinet, Frédéric; Bégel, Valentin; Lopez, Régis; Dellacherie, Delphine; Bella, Simone Dalla Children and adults with Attention-Deficit/Hyperactivity Disorder cannot move to the beat Article de journal Dans: Scientific reports, 7 (1), p. 11550, 2017. @article{Puyjarinet.2017, title = {Children and adults with Attention-Deficit/Hyperactivity Disorder cannot move to the beat}, author = {Frédéric Puyjarinet and Valentin Bégel and Régis Lopez and Delphine Dellacherie and Simone Dalla Bella}, doi = {10.1038/s41598-017-11295-w}, year = {2017}, date = {2017-01-01}, journal = {Scientific reports}, volume = {7}, number = {1}, pages = {11550}, abstract = {Children and adults with Attention-Deficit Hyperactivity Disorder (ADHD) fail in simple tasks like telling whether two sounds have different durations, or in reproducing single durations. The deficit is linked to poor reading, attention, and language skills. Here we demonstrate that these timing distortions emerge also when tracking the beat of rhythmic sounds in perceptual and sensorimotor tasks. This contrasts with the common observation that durations are better perceived and produced when embedded in rhythmic stimuli. Children and adults with ADHD struggled when moving to the beat of rhythmic sounds, and when detecting deviations from the beat. Our findings point to failure in generating an internal beat in ADHD while listening to rhythmic sounds, a function typically associated with the basal ganglia. Rhythm-based interventions aimed at reinstating or compensating this malfunctioning circuitry may be particularly valuable in ADHD, as already shown for other neurodevelopmental disorders, such as dyslexia and Specific Language Impairment.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Children and adults with Attention-Deficit Hyperactivity Disorder (ADHD) fail in simple tasks like telling whether two sounds have different durations, or in reproducing single durations. The deficit is linked to poor reading, attention, and language skills. Here we demonstrate that these timing distortions emerge also when tracking the beat of rhythmic sounds in perceptual and sensorimotor tasks. This contrasts with the common observation that durations are better perceived and produced when embedded in rhythmic stimuli. Children and adults with ADHD struggled when moving to the beat of rhythmic sounds, and when detecting deviations from the beat. Our findings point to failure in generating an internal beat in ADHD while listening to rhythmic sounds, a function typically associated with the basal ganglia. Rhythm-based interventions aimed at reinstating or compensating this malfunctioning circuitry may be particularly valuable in ADHD, as already shown for other neurodevelopmental disorders, such as dyslexia and Specific Language Impairment. |
2015 |
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| 4. | Alonso, Irene; Dellacherie, Delphine; Samson, Séverine Emotional memory for musical excerpts in young and older adults Article de journal Dans: Front Aging Neurosci, 7 , p. 23, 2015, ISSN: 1663-4365. @article{alonso_emotional_2015, title = {Emotional memory for musical excerpts in young and older adults}, author = {Irene Alonso and Delphine Dellacherie and Séverine Samson}, doi = {10.3389/fnagi.2015.00023}, issn = {1663-4365}, year = {2015}, date = {2015-06-01}, journal = {Front Aging Neurosci}, volume = {7}, pages = {23}, abstract = {The emotions evoked by music can enhance recognition of excerpts. It has been suggested that memory is better for high than for low arousing music (Eschrich et al., 2005; Samson et al., 2009), but it remains unclear whether positively (Eschrich et al., 2008) or negatively valenced music (Aubé et al., 2013; Vieillard and Gilet, 2013) may be better recognized. Moreover, we still know very little about the influence of age on emotional memory for music. To address these issues, we tested emotional memory for music in young and older adults using musical excerpts varying in terms of arousal and valence. Participants completed immediate and 24 h delayed recognition tests. We predicted highly arousing excerpts to be better recognized by both groups in immediate recognition. We hypothesized that arousal may compensate consolidation deficits in aging, thus showing more prominent benefit of high over low arousing stimuli in older than younger adults on delayed recognition. We also hypothesized worst retention of negative excerpts for the older group, resulting in a recognition benefit for positive over negative excerpts specific to older adults. Our results suggest that although older adults had worse recognition than young adults overall, effects of emotion on memory do not seem to be modified by aging. Results on immediate recognition suggest that recognition of low arousing excerpts can be affected by valence, with better memory for positive relative to negative low arousing music. However, 24 h delayed recognition results demonstrate effects of emotion on memory consolidation regardless of age, with a recognition benefit for high arousal and for negatively valenced music. The present study highlights the role of emotion on memory consolidation. Findings are examined in light of the literature on emotional memory for music and for other stimuli. We finally discuss the implication of the present results for potential music interventions in aging and dementia.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The emotions evoked by music can enhance recognition of excerpts. It has been suggested that memory is better for high than for low arousing music (Eschrich et al., 2005; Samson et al., 2009), but it remains unclear whether positively (Eschrich et al., 2008) or negatively valenced music (Aubé et al., 2013; Vieillard and Gilet, 2013) may be better recognized. Moreover, we still know very little about the influence of age on emotional memory for music. To address these issues, we tested emotional memory for music in young and older adults using musical excerpts varying in terms of arousal and valence. Participants completed immediate and 24 h delayed recognition tests. We predicted highly arousing excerpts to be better recognized by both groups in immediate recognition. We hypothesized that arousal may compensate consolidation deficits in aging, thus showing more prominent benefit of high over low arousing stimuli in older than younger adults on delayed recognition. We also hypothesized worst retention of negative excerpts for the older group, resulting in a recognition benefit for positive over negative excerpts specific to older adults. Our results suggest that although older adults had worse recognition than young adults overall, effects of emotion on memory do not seem to be modified by aging. Results on immediate recognition suggest that recognition of low arousing excerpts can be affected by valence, with better memory for positive relative to negative low arousing music. However, 24 h delayed recognition results demonstrate effects of emotion on memory consolidation regardless of age, with a recognition benefit for high arousal and for negatively valenced music. The present study highlights the role of emotion on memory consolidation. Findings are examined in light of the literature on emotional memory for music and for other stimuli. We finally discuss the implication of the present results for potential music interventions in aging and dementia. |
| 5. | Omigie, Diana; Dellacherie, Delphine; Hasboun, Dominique; Clément, Sylvain; Baulac, Michel; Adam, Claude; Samson, Séverine Intracranial markers of emotional valence processing and judgments in music Article de journal Dans: Cogn Neurosci, 6 (1), p. 16–23, 2015, ISSN: 1758-8936. @article{omigie_intracranial_2015, title = {Intracranial markers of emotional valence processing and judgments in music}, author = {Diana Omigie and Delphine Dellacherie and Dominique Hasboun and Sylvain Clément and Michel Baulac and Claude Adam and Séverine Samson}, doi = {10.1080/17588928.2014.988131}, issn = {1758-8936}, year = {2015}, date = {2015-02-01}, journal = {Cogn Neurosci}, volume = {6}, number = {1}, pages = {16--23}, abstract = {The involvement of the amygdala and orbitofrontal cortex in the processing of valenced stimuli is well established. However, less is known about the extent to which activity in these regions reflects a stimulus' physical properties, the individual subjective experience it evokes, or both. We recorded cortical electrical activity from five epileptic patients implanted with depth electrodes for presurgical evaluation while they rated "consonant" and "dissonant" musical chords using a "pleasantness" scale. We compared the pattern of responses in the amygdala and orbitofrontal cortex when trials were sorted by pleasantness judgments relative to when they were sorted by the acoustic properties known to influence emotional reactions to musical chords. This revealed earlier differential activity in the amygdala in the physical properties-based, relative to in the judgment-based, analyses. Thus, our results demonstrate that the amygdala has, first and foremost, a high initial sensitivity to the physical properties of valenced stimuli. The finding that differentiations in the amygdala based on pleasantness ratings had a longer latency suggests that in this structure, mediation of emotional judgment follows accumulation of sensory information. This is in contrast to the orbitofrontal cortex where sensitivity to sensory information did not precede differentiation based on affective judgments.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The involvement of the amygdala and orbitofrontal cortex in the processing of valenced stimuli is well established. However, less is known about the extent to which activity in these regions reflects a stimulus' physical properties, the individual subjective experience it evokes, or both. We recorded cortical electrical activity from five epileptic patients implanted with depth electrodes for presurgical evaluation while they rated "consonant" and "dissonant" musical chords using a "pleasantness" scale. We compared the pattern of responses in the amygdala and orbitofrontal cortex when trials were sorted by pleasantness judgments relative to when they were sorted by the acoustic properties known to influence emotional reactions to musical chords. This revealed earlier differential activity in the amygdala in the physical properties-based, relative to in the judgment-based, analyses. Thus, our results demonstrate that the amygdala has, first and foremost, a high initial sensitivity to the physical properties of valenced stimuli. The finding that differentiations in the amygdala based on pleasantness ratings had a longer latency suggests that in this structure, mediation of emotional judgment follows accumulation of sensory information. This is in contrast to the orbitofrontal cortex where sensitivity to sensory information did not precede differentiation based on affective judgments. |
| 6. | Huijgen, J; Dellacherie, D; Tillmann, B; Clément, S; Bigand, E; Dupont, S; Samson, S The feeling of familiarity for music in patients with a unilateral temporal lobe lesion: a gating study Article de journal Dans: Neuropsychologia, 77 , p. 313–320, 2015. @article{huijgen_feeling_2015, title = {The feeling of familiarity for music in patients with a unilateral temporal lobe lesion: a gating study}, author = {J Huijgen and D Dellacherie and B Tillmann and S Clément and E Bigand and S Dupont and S Samson}, doi = {doi:10.1016/j.neuropsychologia.2015.09.007}, year = {2015}, date = {2015-01-01}, journal = {Neuropsychologia}, volume = {77}, pages = {313--320}, abstract = {Previous research has indicated that the medial temporal lobe (MTL), and more specifically the perirhinal cortex, plays a role in the feeling of familiarity for non-musical stimuli. Here, we examined contribution of the MTL to the feeling of familiarity for music by testing patients with unilateral MTL lesions. We used a gating paradigm: segments of familiar and unfamiliar musical excerpts were played with increasing durations (250, 500, 1000, 2000, 4000 ms and complete excerpts), and participants provided familiarity judgments for each segment. Based on the hypothesis that patients might need longer segments than healthy controls (HC) to identify excerpts as familiar, we examined the onset of the emergence of familiarity in HC, patients with a right MTL resection (RTR), and patients with a left MTL resection (LTR). In contrast to our hypothesis, we found that the feeling of familiarity was relatively spared in patients with a right or left MTL lesion, even for short excerpts. All participants were able to differentiate familiar from unfamiliar excerpts as early as 500 ms, although the difference between familiar and unfamiliar judgements was greater in HC than in patients. These findings suggest that a unilateral MTL lesion does not impair the emergence of the feeling of familiarity. We also assessed whether the dynamics of the musical excerpt (linked to the type and amount of information contained in the excerpts) modulated the onset of the feeling of familiarity in the three groups. The difference between familiar and unfamiliar judgements was greater for high than for low-dynamic excerpts for HC and RTR patients, but not for LTR patients. This indicates that the LTR group did not benefit in the same way from dynamics. Overall, our results imply that the recognition of previously well-learned musical excerpts does not depend on the integrity of either right or the left MTL structures. Patients with a unilateral MTL resection may compensate for the effects of unilateral damage by using the intact contralateral temporal lobe. Moreover, we suggest that remote semantic memory for music might depend more strongly on neocortical structures rather than the MTL.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Previous research has indicated that the medial temporal lobe (MTL), and more specifically the perirhinal cortex, plays a role in the feeling of familiarity for non-musical stimuli. Here, we examined contribution of the MTL to the feeling of familiarity for music by testing patients with unilateral MTL lesions. We used a gating paradigm: segments of familiar and unfamiliar musical excerpts were played with increasing durations (250, 500, 1000, 2000, 4000 ms and complete excerpts), and participants provided familiarity judgments for each segment. Based on the hypothesis that patients might need longer segments than healthy controls (HC) to identify excerpts as familiar, we examined the onset of the emergence of familiarity in HC, patients with a right MTL resection (RTR), and patients with a left MTL resection (LTR). In contrast to our hypothesis, we found that the feeling of familiarity was relatively spared in patients with a right or left MTL lesion, even for short excerpts. All participants were able to differentiate familiar from unfamiliar excerpts as early as 500 ms, although the difference between familiar and unfamiliar judgements was greater in HC than in patients. These findings suggest that a unilateral MTL lesion does not impair the emergence of the feeling of familiarity. We also assessed whether the dynamics of the musical excerpt (linked to the type and amount of information contained in the excerpts) modulated the onset of the feeling of familiarity in the three groups. The difference between familiar and unfamiliar judgements was greater for high than for low-dynamic excerpts for HC and RTR patients, but not for LTR patients. This indicates that the LTR group did not benefit in the same way from dynamics. Overall, our results imply that the recognition of previously well-learned musical excerpts does not depend on the integrity of either right or the left MTL structures. Patients with a unilateral MTL resection may compensate for the effects of unilateral damage by using the intact contralateral temporal lobe. Moreover, we suggest that remote semantic memory for music might depend more strongly on neocortical structures rather than the MTL. |
2014 |
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| 7. | Omigie, Diana; Dellacherie, Delphine; Hasboun, Dominique; George, Nathalie; Clement, Sylvain; Baulac, Michel; Adam, Claude; Samson, Severine An Intracranial EEG Study of the Neural Dynamics of Musical Valence Processing Article de journal Dans: Cereb. Cortex, p. bhu118, 2014, ISSN: 1047-3211, 1460-2199. @article{omigie_intracranial_2014, title = {An Intracranial EEG Study of the Neural Dynamics of Musical Valence Processing}, author = {Diana Omigie and Delphine Dellacherie and Dominique Hasboun and Nathalie George and Sylvain Clement and Michel Baulac and Claude Adam and Severine Samson}, url = {http://cercor.oxfordjournals.org/content/early/2014/06/05/cercor.bhu118}, doi = {10.1093/cercor/bhu118}, issn = {1047-3211, 1460-2199}, year = {2014}, date = {2014-06-01}, urldate = {2015-03-26}, journal = {Cereb. Cortex}, pages = {bhu118}, abstract = {The processing of valence is known to recruit the amygdala, orbitofrontal cortex, and relevant sensory areas. However, how these regions interact remains unclear. We recorded cortical electrical activity from 7 epileptic patients implanted with depth electrodes for presurgical evaluation while they listened to positively and negatively valenced musical chords. Time–frequency analysis suggested a specific role of the orbitofrontal cortex in the processing of positively valenced stimuli while, most importantly, Granger causality analysis revealed that the amygdala tends to drive both the orbitofrontal cortex and the auditory cortex in theta and alpha frequency bands, during the processing of valenced stimuli. Results from the current study show the amygdala to be a critical hub in the emotion processing network: specifically one that influences not only the higher order areas involved in the evaluation of a stimulus's emotional value but also the sensory cortical areas involved in the processing of its low-level acoustic features.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The processing of valence is known to recruit the amygdala, orbitofrontal cortex, and relevant sensory areas. However, how these regions interact remains unclear. We recorded cortical electrical activity from 7 epileptic patients implanted with depth electrodes for presurgical evaluation while they listened to positively and negatively valenced musical chords. Time–frequency analysis suggested a specific role of the orbitofrontal cortex in the processing of positively valenced stimuli while, most importantly, Granger causality analysis revealed that the amygdala tends to drive both the orbitofrontal cortex and the auditory cortex in theta and alpha frequency bands, during the processing of valenced stimuli. Results from the current study show the amygdala to be a critical hub in the emotion processing network: specifically one that influences not only the higher order areas involved in the evaluation of a stimulus's emotional value but also the sensory cortical areas involved in the processing of its low-level acoustic features. |
| 8. | Omigie, Diana; Dellacherie, Delphine; Hasboun, Dominique; Clément, Sylvain; Baulac, Michel; Adam, Claude; Samson, Séverine Intracranial markers of emotional valence processing and judgments in music. Article de journal Dans: Cognitive neuroscience, (December), p. 1–8, 2014, ISSN: 1758-8936. @article{omigie_intracranial_2014-1, title = {Intracranial markers of emotional valence processing and judgments in music.}, author = {Diana Omigie and Delphine Dellacherie and Dominique Hasboun and Sylvain Clément and Michel Baulac and Claude Adam and Séverine Samson}, url = {http://www.ncbi.nlm.nih.gov/pubmed/25496511}, doi = {10.1080/17588928.2014.988131}, issn = {1758-8936}, year = {2014}, date = {2014-01-01}, journal = {Cognitive neuroscience}, number = {December}, pages = {1--8}, abstract = {The involvement of the amygdala and orbitofrontal cortex in the processing of valenced stimuli is well established. However, less is known about the extent to which activity in these regions reflects a stimulus' physical properties, the individual subjective experience it evokes, or both. We recorded cortical electrical activity from five epileptic patients implanted with depth electrodes for presurgical evaluation while they rated "consonant" and "dissonant" musical chords using a "pleasantness" scale. We compared the pattern of responses in the amygdala and orbitofrontal cortex when trials were sorted by pleasantness judgments relative to when they were sorted by the acoustic properties known to influence emotional reactions to musical chords. This revealed earlier differential activity in the amygdala in the physical properties-based, relative to in the judgment-based, analyses. Thus, our results demonstrate that the amygdala has, first and foremost, a high initial sensitivity to the physical properties of valenced stimuli. The finding that differentiations in the amygdala based on pleasantness ratings had a longer latency suggests that in this structure, mediation of emotional judgment follows accumulation of sensory information. This is in contrast to the orbitofrontal cortex where sensitivity to sensory information did not precede differentiation based on affective judgments.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The involvement of the amygdala and orbitofrontal cortex in the processing of valenced stimuli is well established. However, less is known about the extent to which activity in these regions reflects a stimulus' physical properties, the individual subjective experience it evokes, or both. We recorded cortical electrical activity from five epileptic patients implanted with depth electrodes for presurgical evaluation while they rated "consonant" and "dissonant" musical chords using a "pleasantness" scale. We compared the pattern of responses in the amygdala and orbitofrontal cortex when trials were sorted by pleasantness judgments relative to when they were sorted by the acoustic properties known to influence emotional reactions to musical chords. This revealed earlier differential activity in the amygdala in the physical properties-based, relative to in the judgment-based, analyses. Thus, our results demonstrate that the amygdala has, first and foremost, a high initial sensitivity to the physical properties of valenced stimuli. The finding that differentiations in the amygdala based on pleasantness ratings had a longer latency suggests that in this structure, mediation of emotional judgment follows accumulation of sensory information. This is in contrast to the orbitofrontal cortex where sensitivity to sensory information did not precede differentiation based on affective judgments. |
| 9. | Delplanque, Jérôme; Devos, David; Huin, Vincent; Genet, Alexandre; Sand, Olivier; Moreau, Caroline; Goizet, Cyril; Charles, Perrine; Anheim, Mathieu; Monin, Marie Lorraine; Buée, Luc; Destée, Alain; Grolez, Guillaume; Delmaire, Christine; Dujardin, Kathy; Dellacherie, Delphine; Brice, Alexis; Stevanin, Giovanni; Strubi-Vuillaume, Isabelle; Dürr, Alexandra; `e, Bernard Sablonni TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment Article de journal Dans: Brain : a journal of neurology, 137 (Pt 10), p. 2657–2663, 2014. @article{Delplanque.2014, title = {TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment}, author = {Jérôme Delplanque and David Devos and Vincent Huin and Alexandre Genet and Olivier Sand and Caroline Moreau and Cyril Goizet and Perrine Charles and Mathieu Anheim and Marie Lorraine Monin and Luc Buée and Alain Destée and Guillaume Grolez and Christine Delmaire and Kathy Dujardin and Delphine Dellacherie and Alexis Brice and Giovanni Stevanin and Isabelle Strubi-Vuillaume and Alexandra Dürr and Bernard Sablonni{`e}re}, doi = {10.1093/brain/awu202}, year = {2014}, date = {2014-01-01}, journal = {Brain : a journal of neurology}, volume = {137}, number = {Pt 10}, pages = {2657--2663}, abstract = {Autosomal dominant cerebellar ataxia corresponds to a clinically and genetically heterogeneous group of neurodegenerative disorders that primarily affect the cerebellum. Here, we report the identification of the causative gene in spinocerebellar ataxia 21, an autosomal-dominant disorder previously mapped to chromosome 7p21.3-p15.1. This ataxia was firstly characterized in a large French family with slowly progressive cerebellar ataxia, accompanied by severe cognitive impairment and mental retardation in two young children. Following the recruitment of 12 additional young family members, linkage analysis enabled us to definitively map the disease locus to chromosome 1p36.33-p36.32. The causative mutation, (c.509CtextgreaterT/p.P170L) in the transmembrane protein gene TMEM240, was identified by whole exome sequencing and then was confirmed by Sanger sequencing and co-segregation analyses. Index cases from 368 French families with autosomal-dominant cerebellar ataxia were also screened for mutations. In seven cases, we identified a range of missense mutations (c.509CtextgreaterT/p.P170L, c.239CtextgreaterT/p.T80M, c.346CtextgreaterT/p.R116C, c.445GtextgreaterA/p.E149K, c.511CtextgreaterT/p.R171W), and a stop mutation (c.489CtextgreaterG/p.Y163*) in the same gene. TMEM240 is a small, strongly conserved transmembrane protein of unknown function present in cerebellum and brain. Spinocerebellar ataxia 21 may be a particular early-onset disease associated with severe cognitive impairment.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Autosomal dominant cerebellar ataxia corresponds to a clinically and genetically heterogeneous group of neurodegenerative disorders that primarily affect the cerebellum. Here, we report the identification of the causative gene in spinocerebellar ataxia 21, an autosomal-dominant disorder previously mapped to chromosome 7p21.3-p15.1. This ataxia was firstly characterized in a large French family with slowly progressive cerebellar ataxia, accompanied by severe cognitive impairment and mental retardation in two young children. Following the recruitment of 12 additional young family members, linkage analysis enabled us to definitively map the disease locus to chromosome 1p36.33-p36.32. The causative mutation, (c.509CtextgreaterT/p.P170L) in the transmembrane protein gene TMEM240, was identified by whole exome sequencing and then was confirmed by Sanger sequencing and co-segregation analyses. Index cases from 368 French families with autosomal-dominant cerebellar ataxia were also screened for mutations. In seven cases, we identified a range of missense mutations (c.509CtextgreaterT/p.P170L, c.239CtextgreaterT/p.T80M, c.346CtextgreaterT/p.R116C, c.445GtextgreaterA/p.E149K, c.511CtextgreaterT/p.R171W), and a stop mutation (c.489CtextgreaterG/p.Y163*) in the same gene. TMEM240 is a small, strongly conserved transmembrane protein of unknown function present in cerebellum and brain. Spinocerebellar ataxia 21 may be a particular early-onset disease associated with severe cognitive impairment. |
2011 |
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| 10. | Dellacherie, D; Bigand, E; Molin, P; Baulac, M; Samson, S Multidimensional scaling of emotional responses to music in patients with temporal lobe resection Article de journal Dans: Cortex, 47 (9), p. 1107–1115, 2011, ISSN: 0010-9452. @article{dellacherie_multidimensional_2011, title = {Multidimensional scaling of emotional responses to music in patients with temporal lobe resection}, author = {D Dellacherie and E Bigand and P Molin and M Baulac and S Samson}, url = {http://www.sciencedirect.com/science/article/pii/S0010945211001511}, doi = {10.1016/j.cortex.2011.05.007}, issn = {0010-9452}, year = {2011}, date = {2011-10-01}, urldate = {2015-03-26}, journal = {Cortex}, volume = {47}, number = {9}, pages = {1107--1115}, abstract = {The present study investigated emotional responses to music by using multidimensional scaling (MDS) analysis in patients with right or left medial temporal lobe (MTL) lesions and matched normal controls (NC). Participants were required to evaluate emotional dissimilarities of nine musical excerpts that were selected to express graduated changes along the valence and arousal dimensions. For this purpose, they rated dissimilarity between pairs of stimuli on an eight-point scale and the resulting matrices were submitted to an MDS analysis. The results showed that patients did not differ from NC participants in evaluating emotional feelings induced by the musical excerpts, suggesting that all participants were able to distinguish refined emotions. We concluded that the ability to detect and use emotional valence and arousal when making dissimilarity judgments was not strongly impaired by a right or left MTL lesion. This finding has important clinical implications and is discussed in light of current neuropsychological studies on emotion. It suggests that emotional responses to music can be at least partially preserved at a non-verbal level in patients with unilateral temporal lobe damage including the amygdala.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The present study investigated emotional responses to music by using multidimensional scaling (MDS) analysis in patients with right or left medial temporal lobe (MTL) lesions and matched normal controls (NC). Participants were required to evaluate emotional dissimilarities of nine musical excerpts that were selected to express graduated changes along the valence and arousal dimensions. For this purpose, they rated dissimilarity between pairs of stimuli on an eight-point scale and the resulting matrices were submitted to an MDS analysis. The results showed that patients did not differ from NC participants in evaluating emotional feelings induced by the musical excerpts, suggesting that all participants were able to distinguish refined emotions. We concluded that the ability to detect and use emotional valence and arousal when making dissimilarity judgments was not strongly impaired by a right or left MTL lesion. This finding has important clinical implications and is discussed in light of current neuropsychological studies on emotion. It suggests that emotional responses to music can be at least partially preserved at a non-verbal level in patients with unilateral temporal lobe damage including the amygdala. |
| 11. | Dellacherie, D; Hasboun, D; Baulac, M; Belin, P; Samson, S Impaired recognition of fear in voices and reduced anxiety after unilateral temporal lobe resection Article de journal Dans: Neuropsychologia, 49 (4), p. 618–629, 2011, ISSN: 0028-3932. @article{dellacherie_impaired_2011, title = {Impaired recognition of fear in voices and reduced anxiety after unilateral temporal lobe resection}, author = {D Dellacherie and D Hasboun and M Baulac and P Belin and S Samson}, url = {http://www.sciencedirect.com/science/article/pii/S0028393210004768}, doi = {10.1016/j.neuropsychologia.2010.11.008}, issn = {0028-3932}, year = {2011}, date = {2011-03-01}, urldate = {2015-03-26}, journal = {Neuropsychologia}, volume = {49}, number = {4}, pages = {618--629}, series = {The Human Amygdala and Emotional Function}, abstract = {It has been reported that bilateral amygdala damage in humans compromises the recognition of fear and anger in nonverbal vocalizations (Scott et al., 1997). We addressed the possibility that unilateral temporal lobe damage might be sufficient to impair fear recognition in voices. For this purpose, we tested patients after left (n = 10) or right (n = 8) medial temporal lobe resection for the relief of intractable epilepsy using a set of nonverbal vocalizations (Belin, Fillion-Bilodeau, & Gosselin, 2008). To focus more narrowly on the role of amygdala subparts, we differentiated patients with complete amygdala damage vs. damage limited to the basolateral complex of the amygdala. The results confirmed for the first time that unilateral amygdala lesion including the basolateral complex can selectively impair recognition of fear and surprise expressed by voices, supporting the notion that the amygdala is a multimodal structure. Interestingly, this impairment was observed in patients with incomplete resection of the amygdala that spared the central nucleus and the corticomedial complex, suggesting that a resection of the basolateral complex is sufficient to affect fear recognition. Given that fear has often been considered as a precursor of anxiety, we also investigated the effect of such lesions on self-reported anxiety. The same patients appeared to be less anxious than control participants in their mood questionnaires. The association of impaired fear perception and decreased anxiety level is considered in the light of recent human and animal data, providing support for a neurobiological basis of mood changes in patients with unilateral temporal lobe damage.}, keywords = {}, pubstate = {published}, tppubtype = {article} } It has been reported that bilateral amygdala damage in humans compromises the recognition of fear and anger in nonverbal vocalizations (Scott et al., 1997). We addressed the possibility that unilateral temporal lobe damage might be sufficient to impair fear recognition in voices. For this purpose, we tested patients after left (n = 10) or right (n = 8) medial temporal lobe resection for the relief of intractable epilepsy using a set of nonverbal vocalizations (Belin, Fillion-Bilodeau, & Gosselin, 2008). To focus more narrowly on the role of amygdala subparts, we differentiated patients with complete amygdala damage vs. damage limited to the basolateral complex of the amygdala. The results confirmed for the first time that unilateral amygdala lesion including the basolateral complex can selectively impair recognition of fear and surprise expressed by voices, supporting the notion that the amygdala is a multimodal structure. Interestingly, this impairment was observed in patients with incomplete resection of the amygdala that spared the central nucleus and the corticomedial complex, suggesting that a resection of the basolateral complex is sufficient to affect fear recognition. Given that fear has often been considered as a precursor of anxiety, we also investigated the effect of such lesions on self-reported anxiety. The same patients appeared to be less anxious than control participants in their mood questionnaires. The association of impaired fear perception and decreased anxiety level is considered in the light of recent human and animal data, providing support for a neurobiological basis of mood changes in patients with unilateral temporal lobe damage. |
| 12. | Dellacherie, Delphine; Roy, Mathieu; Hugueville, Laurent; Peretz, Isabelle; Samson, Séverine The effect of musical experience on emotional self-reports and psychophysiological responses to dissonance Article de journal Dans: Psychophysiology, 48 (3), p. 337–349, 2011, ISSN: 1469-8986. @article{dellacherie_effect_2011, title = {The effect of musical experience on emotional self-reports and psychophysiological responses to dissonance}, author = {Delphine Dellacherie and Mathieu Roy and Laurent Hugueville and Isabelle Peretz and Séverine Samson}, url = {http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8986.2010.01075.x/abstract}, doi = {10.1111/j.1469-8986.2010.01075.x}, issn = {1469-8986}, year = {2011}, date = {2011-01-01}, urldate = {2015-03-26}, journal = {Psychophysiology}, volume = {48}, number = {3}, pages = {337--349}, abstract = {To study the influence of musical education on emotional reactions to dissonance, we examined self-reports and physiological responses to dissonant and consonant musical excerpts in listeners with low (LE: n=15) and high (HE: n=13) musical experience. The results show that dissonance induces more unpleasant feelings and stronger physiological responses in HE than in LE participants, suggesting that musical education reinforces aversion to dissonance. Skin conductance (SCR) and electromyographic (EMG) signals were analyzed according to a defense cascade model, which takes into account two successive time windows corresponding to orienting and defense responses. These analyses suggest that musical experience can influence the defense response to dissonance and demonstrate a powerful role of musical experience not only in autonomic but also in expressive responses to music.}, keywords = {}, pubstate = {published}, tppubtype = {article} } To study the influence of musical education on emotional reactions to dissonance, we examined self-reports and physiological responses to dissonant and consonant musical excerpts in listeners with low (LE: n=15) and high (HE: n=13) musical experience. The results show that dissonance induces more unpleasant feelings and stronger physiological responses in HE than in LE participants, suggesting that musical education reinforces aversion to dissonance. Skin conductance (SCR) and electromyographic (EMG) signals were analyzed according to a defense cascade model, which takes into account two successive time windows corresponding to orienting and defense responses. These analyses suggest that musical experience can influence the defense response to dissonance and demonstrate a powerful role of musical experience not only in autonomic but also in expressive responses to music. |
| 13. | Dellacherie, D; Bigand, E; Molin, P; Baulac, M; Samson, S Multidimensional scaling of emotional responses to music in patients with temporal lobe resection Article de journal Dans: Cortex, 47 (9), p. 1107–1115, 2011, ISSN: 0010-9452. @article{dellacherie_multidimensional_2011-1, title = {Multidimensional scaling of emotional responses to music in patients with temporal lobe resection}, author = {D Dellacherie and E Bigand and P Molin and M Baulac and S Samson}, url = {http://www.sciencedirect.com/science/article/pii/S0010945211001511}, doi = {10.1016/j.cortex.2011.05.007}, issn = {0010-9452}, year = {2011}, date = {2011-01-01}, urldate = {2015-03-26}, journal = {Cortex}, volume = {47}, number = {9}, pages = {1107--1115}, abstract = {The present study investigated emotional responses to music by using multidimensional scaling (MDS) analysis in patients with right or left medial temporal lobe (MTL) lesions and matched normal controls (NC). Participants were required to evaluate emotional dissimilarities of nine musical excerpts that were selected to express graduated changes along the valence and arousal dimensions. For this purpose, they rated dissimilarity between pairs of stimuli on an eight-point scale and the resulting matrices were submitted to an MDS analysis. The results showed that patients did not differ from NC participants in evaluating emotional feelings induced by the musical excerpts, suggesting that all participants were able to distinguish refined emotions. We concluded that the ability to detect and use emotional valence and arousal when making dissimilarity judgments was not strongly impaired by a right or left MTL lesion. This finding has important clinical implications and is discussed in light of current neuropsychological studies on emotion. It suggests that emotional responses to music can be at least partially preserved at a non-verbal level in patients with unilateral temporal lobe damage including the amygdala.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The present study investigated emotional responses to music by using multidimensional scaling (MDS) analysis in patients with right or left medial temporal lobe (MTL) lesions and matched normal controls (NC). Participants were required to evaluate emotional dissimilarities of nine musical excerpts that were selected to express graduated changes along the valence and arousal dimensions. For this purpose, they rated dissimilarity between pairs of stimuli on an eight-point scale and the resulting matrices were submitted to an MDS analysis. The results showed that patients did not differ from NC participants in evaluating emotional feelings induced by the musical excerpts, suggesting that all participants were able to distinguish refined emotions. We concluded that the ability to detect and use emotional valence and arousal when making dissimilarity judgments was not strongly impaired by a right or left MTL lesion. This finding has important clinical implications and is discussed in light of current neuropsychological studies on emotion. It suggests that emotional responses to music can be at least partially preserved at a non-verbal level in patients with unilateral temporal lobe damage including the amygdala. |
2009 |
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| 14. | Dellacherie, Delphine; Pfeuty, Micha; Hasboun, Dominique; Lefèvre, Julien; Hugueville, Laurent; Schwartz, Denis P; Baulac, Michel; Adam, Claude; Samson, Séverine The birth of musical emotion: a depth electrode case study in a human subject with epilepsy Article de journal Dans: Ann. N. Y. Acad. Sci., 1169 , p. 336–341, 2009, ISSN: 1749-6632. @article{dellacherie_birth_2009, title = {The birth of musical emotion: a depth electrode case study in a human subject with epilepsy}, author = {Delphine Dellacherie and Micha Pfeuty and Dominique Hasboun and Julien Lefèvre and Laurent Hugueville and Denis P Schwartz and Michel Baulac and Claude Adam and Séverine Samson}, doi = {10.1111/j.1749-6632.2009.04870.x}, issn = {1749-6632}, year = {2009}, date = {2009-07-01}, journal = {Ann. N. Y. Acad. Sci.}, volume = {1169}, pages = {336--341}, abstract = {Intracranial electroencephalography was recorded in an epileptic patient when he was listening to dissonant and consonant chords and to minor and major chords. Changes in dissonance induced event-related potentials (ERPs) in the auditory areas from 200 ms onward, in the orbito-frontal cortex (500-1000 ms), and later in the amygdala and anterior cingulate gyrus (1200-1400 ms), suggesting the sequential involvement of these brain structures in implicit emotional judgment of musical dissonance. Changes in musical mode induced ERPs only in the orbito-frontal cortex (500-1000 ms), emphasizing the implication of this frontal region in emotional judgment of pleasant music.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Intracranial electroencephalography was recorded in an epileptic patient when he was listening to dissonant and consonant chords and to minor and major chords. Changes in dissonance induced event-related potentials (ERPs) in the auditory areas from 200 ms onward, in the orbito-frontal cortex (500-1000 ms), and later in the amygdala and anterior cingulate gyrus (1200-1400 ms), suggesting the sequential involvement of these brain structures in implicit emotional judgment of musical dissonance. Changes in musical mode induced ERPs only in the orbito-frontal cortex (500-1000 ms), emphasizing the implication of this frontal region in emotional judgment of pleasant music. |
| 15. | Dellacherie, Delphine; Pfeuty, Micha; Hasboun, Dominique; Lefèvre, Julien; Hugueville, Laurent; Schwartz, Denis P; Baulac, Michel; Adam, Claude; Samson, Séverine The Birth of Musical Emotion Article de journal Dans: Annals of the New York Academy of Sciences, 1169 (1), p. 336–341, 2009, ISSN: 1749-6632. @article{dellacherie_birth_2009-1, title = {The Birth of Musical Emotion}, author = {Delphine Dellacherie and Micha Pfeuty and Dominique Hasboun and Julien Lefèvre and Laurent Hugueville and Denis P Schwartz and Michel Baulac and Claude Adam and Séverine Samson}, url = {http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.04870.x/abstract}, doi = {10.1111/j.1749-6632.2009.04870.x}, issn = {1749-6632}, year = {2009}, date = {2009-01-01}, urldate = {2015-03-26}, journal = {Annals of the New York Academy of Sciences}, volume = {1169}, number = {1}, pages = {336--341}, abstract = {Intracranial electroencephalography was recorded in an epileptic patient when he was listening to dissonant and consonant chords and to minor and major chords. Changes in dissonance induced event-related potentials (ERPs) in the auditory areas from 200 ms onward, in the orbito-frontal cortex (500–1000 ms), and later in the amygdala and anterior cingulate gyrus (1200–1400 ms), suggesting the sequential involvement of these brain structures in implicit emotional judgment of musical dissonance. Changes in musical mode induced ERPs only in the orbito-frontal cortex (500–1000 ms), emphasizing the implication of this frontal region in emotional judgment of pleasant music.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Intracranial electroencephalography was recorded in an epileptic patient when he was listening to dissonant and consonant chords and to minor and major chords. Changes in dissonance induced event-related potentials (ERPs) in the auditory areas from 200 ms onward, in the orbito-frontal cortex (500–1000 ms), and later in the amygdala and anterior cingulate gyrus (1200–1400 ms), suggesting the sequential involvement of these brain structures in implicit emotional judgment of musical dissonance. Changes in musical mode induced ERPs only in the orbito-frontal cortex (500–1000 ms), emphasizing the implication of this frontal region in emotional judgment of pleasant music. |
| 16. | Samson, Séverine; Dellacherie, Delphine; Platel, Hervé Emotional power of music in patients with memory disorders: clinical implications of cognitive neuroscience Article de journal Dans: Ann. N. Y. Acad. Sci., 1169 , p. 245–255, 2009, ISSN: 1749-6632. @article{samson_emotional_2009, title = {Emotional power of music in patients with memory disorders: clinical implications of cognitive neuroscience}, author = {Séverine Samson and Delphine Dellacherie and Hervé Platel}, doi = {10.1111/j.1749-6632.2009.04555.x}, issn = {1749-6632}, year = {2009}, date = {2009-01-01}, journal = {Ann. N. Y. Acad. Sci.}, volume = {1169}, pages = {245--255}, abstract = {By adapting methods of cognitive psychology to neuropsychology, we examined memory and familiarity abilities in music in relation to emotion. First we present data illustrating how the emotional content of stimuli influences memory for music. Second, we discuss recent findings obtained in patients with two different brain disorders (medically intractable epilepsy and Alzheimer's disease) that show relatively spared memory performance for music, despite severe verbal memory disorders. Studies on musical memory and its relation to emotion open up paths for new strategies in cognitive rehabilitation and reinstate the importance of examining interactions between cognitive and clinical neurosciences.}, keywords = {}, pubstate = {published}, tppubtype = {article} } By adapting methods of cognitive psychology to neuropsychology, we examined memory and familiarity abilities in music in relation to emotion. First we present data illustrating how the emotional content of stimuli influences memory for music. Second, we discuss recent findings obtained in patients with two different brain disorders (medically intractable epilepsy and Alzheimer's disease) that show relatively spared memory performance for music, despite severe verbal memory disorders. Studies on musical memory and its relation to emotion open up paths for new strategies in cognitive rehabilitation and reinstate the importance of examining interactions between cognitive and clinical neurosciences. |
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